POS1355 THE REMITTING SERONEGATIVE SYMMETRICAL SYNOVITIS WITH PITTING EDEMA SYNDROME (RS3PE): REVIEW OF TEN YEARS AT A REFERENCE HOSPITAL

Background: The Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome (RS3PE) is a rare rheumatological disease, considered benign process. Objectives: This study aims to describe its clinical features and serological markers, also analyze possible association neoplasms. Methods: An observational retrospective was performed assess demographic characteristics of patients diagnosed from RS3PE at reference hospital amongst the Rheumatology Internal Medicine departments, 2010 2021. Results: Twenty-seven were included, mean age 82.74 y.o. (IC95% 80.45-85.04; range 66 93), 51.85% proportion males. Only 22.22% rural areas. All presented bilateral hand edema although some associated feet (40.74%) or morning stiffness (70.37%). Blood tests demonstrated anemia in 44.44% patients. Inflammatory markers elevated, such as C-Reactive Protein (29.23 mg/L, IC95% 18.17-40.29), erythrocyte-sedimentation rate (33.74 mm/hour, 24.22-43.26) fibrinogen (531.6 mg/dL, 482.91-580.30). few any autoimmune marker antinuclear antibodies (18.18%) rheumatoid factor (8.70%). X-ray screening realized 22 14 showed osteoarthritis radiologic presentation, 4 had radiological findings chondrocalcinosis one them both. patient bone erosion. Malignancy diagnosis only 29.63% (all negative). During follow-up two tumors detected (mean accumulated follow-up: 40.37 months, 26.70-54.04; 1 122) there adenocarcinoma primary but received low-dose corticosteroids, good rapid response all cases. Three treatment methotrexate (2) leflunomide (1). Conclusion: must be contemplated elderly presenting pitting articular symptoms. No specific biomarkers have been described, inflammatory reaction often found absence arthritis biomarkers. Rapid corticosteroids prevalent. neoplasms during follow-up. References: [1]Paira S, Graf C, Roverano Rossini J. seronegative symmetrical synovitis oedema: 12 Clin Rheumatol. 2002 May;21(2):146-9. doi: 10.1007/pl00011218. PMID: 12086166. [2]Cobeta García JC, Martínez Burgui syndrome edematous polysynovitis elderly. Study 8 Rev Esp. 1999 Dec;199(12):785-9. Spanish. 10687410. [3]Moreno Obregón F, Del Castillo Madrigal M, Díaz Narváez Pérez Delgado FJ. positive factor. Reumatol Clin. 2019 Nov-Dec;15(6):e168-e169. English, 10.1016/j.reuma.2017.11.009. Epub 2017 Dec 15. 29254743 Disclosure Interests: None declared